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The last proposed mechanism of RBC vasodilation while in the existence of nitrite could be the reduction of nitrite to NO by Hb. Brooks initially researched the nitrite Hb conversation in 1937 which perform was later prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to type metHb and NO (Brooks, 1937